Is Hyperthermic Mitomycin an effective second line treatment in non-muscle invasive bladder cancer?
Author(s):
Miss Maria Vedanayagam
,
Miss Maria Vedanayagam
Affiliations:
Mrs Angela Elliott
,
Mrs Angela Elliott
Affiliations:
Professor Sanjeev Madaan
Professor Sanjeev Madaan
Affiliations:
BAUS ePoster online library. Satchi M. 06/26/17; 177331; P1-3
Ms. Maria Satchi
Ms. Maria Satchi
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Abstract
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Introduction:

There is no proven effective treatment for patients with non-muscle invasive bladder cancer with post-BCG tumour recurrence. Radiofrequency-Induced ‎Thermo-Chemotherapy Effect (RITE) using MMC has been proposed as a treatment for post-BCG recurrence.

Aims and Objectives:

The aim of this study was to assess the efficacy of RITE + MMC in patients with recurrent NMIBC despite BCG treatment and patients intolerant of the toxic effects of BCG. The primary end point was to assess the recurrence free survival at 12 months.

Method:
A prospective database was maintained for all patients who received RITE from November 2011 to April 2015 with a minimum follow up period of 12 months.

Results:

25 patients received Synergo® RITE + MMC and were followed up for a minimum of 12 months. Following treatment, in 9/25 (36%) patients there was evidence of disease recurrence, however 3 patients had recurrence of disease >12 months from commencing treatment. 16/25 (68%) remain recurrence free to date. This gives an overall 12-month survival free recurrence rate of 76%. We recognise that the rate of side effects causing cessation of treatment was above 50%. The mean recurrence free period was 19.5 months.

Conclusion:

These preliminary results show that RITE + MMC is a useful second line agent to consider in patients with recurrent NMIBC who are unfit or unwilling to have a cystectomy.

Introduction:

There is no proven effective treatment for patients with non-muscle invasive bladder cancer with post-BCG tumour recurrence. Radiofrequency-Induced ‎Thermo-Chemotherapy Effect (RITE) using MMC has been proposed as a treatment for post-BCG recurrence.

Aims and Objectives:

The aim of this study was to assess the efficacy of RITE + MMC in patients with recurrent NMIBC despite BCG treatment and patients intolerant of the toxic effects of BCG. The primary end point was to assess the recurrence free survival at 12 months.

Method:
A prospective database was maintained for all patients who received RITE from November 2011 to April 2015 with a minimum follow up period of 12 months.

Results:

25 patients received Synergo® RITE + MMC and were followed up for a minimum of 12 months. Following treatment, in 9/25 (36%) patients there was evidence of disease recurrence, however 3 patients had recurrence of disease >12 months from commencing treatment. 16/25 (68%) remain recurrence free to date. This gives an overall 12-month survival free recurrence rate of 76%. We recognise that the rate of side effects causing cessation of treatment was above 50%. The mean recurrence free period was 19.5 months.

Conclusion:

These preliminary results show that RITE + MMC is a useful second line agent to consider in patients with recurrent NMIBC who are unfit or unwilling to have a cystectomy.

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