Testicular cancer and male fertility; Abnormalities detected and Aetio-pathogenesis
Author(s):
Mr Khaled Almekaty
,
Mr Khaled Almekaty
Affiliations:
Mr Chris Poullis
,
Mr Chris Poullis
Affiliations:
Mr Mohamed Zahran
,
Mr Mohamed Zahran
Affiliations:
Mr Gideon Blecher
,
Mr Gideon Blecher
Affiliations:
Mr Tet Yap
,
Mr Tet Yap
Affiliations:
Mr Suks Minhas
Mr Suks Minhas
Affiliations:
BAUS ePoster online library. Almekaty K. 06/27/17; 177381; P4-15
Dr. Khaled Almekaty
Dr. Khaled Almekaty
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Abstract
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Objectives:
The association of testis cancer and infertility has been reported, although the pathogenesis is unknown. The aim of this study was to determine if pathological variables had an effect on semen parameters.

Materials and methods:
110 men underwent sperm cryopreservation prior to orchidectomy. Multiple regression analysis was used to determine the effects of age, tumour size, histopathology and tumour markers on semen parameters.

Results:
Median age was 31 years (IQR 25-35). Sperm concentration, motility and normal forms were 17.15 million/ml, 54.25% and 6.5% respectively. Seminomatous tumours were associated with better motility than other tumour types (p = 0.048), whereas tumours with higher AFP were associated with poorer morphology (p= 0.02). Median AFP was 3 (IQR2.6-12.5). 49 patients (44.5%) had OAT, 8 were azoospermic (7.3%) and 38 had oligozoospermia (34.5%).No other factors were associated with semen parameters. (table 1)

Conclusion:
44.5% of patients with testicular cancer had abnormalities in their semen parameters, with azoospermia in 7.3%. Surprisingly, these abnormalities are unrelated to tumour size or stage and needs further investigation.



Objectives:
The association of testis cancer and infertility has been reported, although the pathogenesis is unknown. The aim of this study was to determine if pathological variables had an effect on semen parameters.

Materials and methods:
110 men underwent sperm cryopreservation prior to orchidectomy. Multiple regression analysis was used to determine the effects of age, tumour size, histopathology and tumour markers on semen parameters.

Results:
Median age was 31 years (IQR 25-35). Sperm concentration, motility and normal forms were 17.15 million/ml, 54.25% and 6.5% respectively. Seminomatous tumours were associated with better motility than other tumour types (p = 0.048), whereas tumours with higher AFP were associated with poorer morphology (p= 0.02). Median AFP was 3 (IQR2.6-12.5). 49 patients (44.5%) had OAT, 8 were azoospermic (7.3%) and 38 had oligozoospermia (34.5%).No other factors were associated with semen parameters. (table 1)

Conclusion:
44.5% of patients with testicular cancer had abnormalities in their semen parameters, with azoospermia in 7.3%. Surprisingly, these abnormalities are unrelated to tumour size or stage and needs further investigation.



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