Urinary stones and intervention quality of life (USIQOL): Development of a new comprehensive patient reported outcome measure
BAUS ePoster online library. Joshi H.
Jun 26, 2018; 211309
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Mr. Hrishi Joshi
Mr. Hrishi Joshi
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Introduction: Urolithiasis and treatments can have significant impact on patients' health-related quality of life (HRQoL). We developed Urinary stones and Intervention quality of Life (USIQoL), a new multidimensional PROM.

Methods: Adult patients with urinary stones covering all index stone categories were asked to participate in different phases (over 350 patients). Phase 1 included literature review and qualitative research that formed the foundation for the initial long draft of the USIQoL. Phase 2 included cognitive debriefing, pilot testing. Phase 3 involved RASCH analysis (partial credit model) and validity and reliability assessments to develop the final draft.

Results: Mean patient age was 51 years (range 18-92) with male patient predominance. Phase 1 studies involved 80 patients and 30 family members. The results identified significant negative QoL impact affecting pain, physical and psycho-social domains along with concerns, specific to stones and treatments. The thematic analyses formed the basis for the initial 60 item draft. Phase 2 confirmed content validity with all stakeholders. In phase 3 the RASCH polytomous analysis identified redundant items and helped develop final version with good item, personal fit and satisfactory separation index. The measure covers all relevant domains of stone and intervention specific factors. The validation studies showed questionnaire to be internally consistent (Cronebach's alpha>0.7) and reliable (Pearson coefficient>0.8) with satisfactory sensitivity to change (p<0.01).

Conclusion: The new USIQoL is a comprehensive valid PROM developed using rigorous standards in measurement studies. It is expected to serve as a standard PROM to evaluate impact of stone disease and treatments.
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