Image fusion targeted prostate biopsy in 740 men at risk: a multicentre evaluation showing low diagnostic yield of significant cancer in non-targeted biopsies
BAUS ePoster online library. Miah S. Jun 26, 2018; 211336
Mr. Saiful Miah
Mr. Saiful Miah
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Abstract
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Introduction: In this large UK multi-centre, prospective series, we compared the diagnostic yield of clinically-significant prostate cancer (csPCa) in image-fusion targeted and non-targeted biopsies.

Patients and Methods: 740 men had transperineal image-fusion targeted prostate biopsies (MIM-Symphony-DXTM) between April 2014 and June 2017 by 11 urologists.

Results: Mean age, median PSA and median prostate volume were 63.2 years, 6.3ng/ml and 43cc respectively. Overall, 341(46.1%) were diagnosed with csPCa (Gleason >/=4+3 or any grade >/=6mm) from the 740 men undergoing biopsy. In 378 men undergoing targeted and non-targeted biopsies, 182 (48%) had csPCa. Only 14 men (3.7%) who underwent both targeted and non-targeted biopsies were discovered to have csPCa in the non-targeted cores alone. 13 out of these 14 men had a PSA <10. Of these men 2 had Gleason 4+3=7 disease and the rest were discovered to have < / = Gleason 3+4 disease. Insignificant cancer exclusively occurred in non-targeted prostate cores in 34 men (9%).

Conclusions: In this large multi-centre series, the added benefit of non-targeted cores is low. An image-fusion targeted-biopsy only has a high detection of csPCa and reduced over-detection of insignificant cancers.
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