9p chromosomal deletion on array-based copy number analysis predicts recurrence in non-metastatic clear cell renal cell carcinoma (ccRCC) following surgical resection
BAUS ePoster online library. Quddus B. 06/27/18; 211376; P9-4
Mr. Bilal Quddus
Mr. Bilal Quddus
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Background: Copy number variations (CNVs) affect biological and clinical behavior of cancers. The aim of this study was to assess CNVs in tumour tissue of a historic group of patients with clear cell RCC.

Methods: 38 consecutive ccRCC cases with median follow up of 81.5 months were identified from Tayside Tissue Bank archive. Histology was confirmed by specialist uro-pathologist. DNA extracted from Fresh frozen samples in 33 cases was analysed with CytoChipOligo™ BlueGenome (Illumina®). Affymetrix OncoScan® FFPE assay was employed to analyse highly degraded DNA extracted from 5 FFPE samples. Nexus software (Biodiscovery®) version 7.5 was used to analyse array based data. Cox-proportional hazard survival analysis for recurrence-free survival (RFS) was performed.

Results: Mean age of cohort was 65 years. Loss of 3p was detected in 95% of the tumours. Other common chromosomal CNVs detected were deletions of 4q (34%), 9p (34%), 14q (34%) and 18q (34%). Common gains included 5q (50%) and 7q (23%). Only 9p deletion was associated with high grade tumours. Ten out of 32 cases with localised ccRCC at diagnosis developed recurrence, with a median follow up of 86.5 months. Out of all clinico-pathological and CNVs, somatic deletion of chromosome 9p was the only significant predictor of recurrence (p=0.002; Hazard ratio: 8.8).

Conclusion: The study confirms that 9p deletion is one of the most common CNVs in ccRCC. Moreover, this is the first array based analysis study, with follow up exceeding 7 years, showing that 9p deletion is associated with higher of recurrence in non-metastatic ccRCC.
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