Variability and quality of outcome reporting in clinical trials of interventions for renal calculi.
BAUS ePoster online library. Cui H. Jun 24, 2019; 259465; P1-6
Ms. Helen Cui
Ms. Helen Cui
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Abstract
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Purpose
To systematically review the quality and consistency of outcome reporting in clinical trials of interventions for renal calculi.

METHODS

We searched the MEDLINE and Cochrane Library database for all full-text articles in English of randomised controlled trials (RCT) comparing two, or more, of either: shockwave lithotripsy, retrograde intrarenal surgery or percutaneous nephrolithotomy, for the treatment of renal calculi, from 2000. Demographic and outcomes data were extracted. Quality of outcome reporting was assessed based on both the clarity of the definition, and completeness of the results, of the primary outcome.

RESULTS

82 primary and secondary outcomes were analysed from 13 RCTs (1144 participants) that met the inclusion criteria. All studies which specified a primary outcome had complete reporting in the results that would allow inclusion in a meta-analysis. 4 studies (30%) had no clearly defined primary outcome measure. 12/13 studies used stone free rate (SFR) as the primary outcome, but every study had a different definition of SFR. 9 studies allowed residual fragments ranging from 2mm to 5mm, but with no description of a method of fragment quantification. Only 4 studies included quality of life as a secondary outcome measure.

CONCLUSION

Although descriptive statistics are reported well, there is variability in the selection and definition of study endpoints. Interpretation and comparison of the evidence for renal stone treatment relies on good quality outcome reporting with a clear definition of the primary and secondary outcomes. A core outcome set for trials in renal stone interventions would benefit future studies.
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