Analysis of kidney stone composition in a contemporary, large, region wide cohort from the UK; are things really changing?
BAUS ePoster online library. Rogers A. Jun 25, 2019; 259482; P11-8
Mr. Alistair Rogers
Mr. Alistair Rogers
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Abstract
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Introduction
Information on kidney stone characteristics is based on historical cohort data. There have been well documented changes in obesity rates in regions of the UK and metabolic syndrome is an important risk factor in urolithiasis. Our aim was to analyse stone composition in a large, current, region wide cohort to assess for potential changes.
Methods
A central pathology centre analyses all renal stones within the region utilising Nicolet 380 FTIR spectrometry. This database was analysed for all renal tract stones between years 2013-2018. Non-Renal/Ureteric stones were excluded. 5998 were included in the study. In mixed stones the predominant type was when >50%. Open access government data on obesity was analysed.
Results
Median age was 57 and Male:Female ratio 1.8:1. Data from 10 hospitals was included. 63% were pure stones and 80% calcium based. Stone compositions are described in table 1. Overweight and obesity nationally have increased from 53% (1993) to 61% (2016). In parts of our region it is as high as 74%.
Discussion
To the best of our knowledge this is one of the largest contemporary cohorts of renal stone characteristics in the UK and Europe. It provides valuable insights into the current biochemical status of urolithiasis. Despite increasing obesity levels there was no increase in proportion of uric acid stones compared to previous studies. Incidence of stones in females is marginally higher than historical series and warrants investigation. Further work is underway to match serum and urine biochemistry data to stone composition.
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