Racial Disparities in Uric Acid Stones: Single centre cohort study
BAUS ePoster online library. Subramonian K. Jun 25, 2019; 259483; P11-9 Disclosure(s): None
Mr. K Subramonian
Mr. K Subramonian
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Abstract
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Introduction: Common risk factors for Uric acid stones based on studies from Caucasian population are older age, high BMI, hyperuricemia, hyperuricosuria and acidic urinary pH. Little is known about the differences in patient characteristics between patients from different ethnic backgrounds. We aim to analyse differences in patient characteristics in uric acid stones.

METHODS:
Stone analysis data from 446 patients were analysed retrospectively. Patients with Uric acid stones were identified and their age, BMI, serum uric acid level and urine pH was compared amongst different patient populations using SPSS. Mann Whitney test was used due to asymmetric distribution of data.

RESULTS:
Calcium oxalate was the commonest stone (n=301,67.5%) followed by uric acid (n=42, 9.4%). Comparison of different patient characteristics in the uric acid group between Caucasian and Asian populations are shown on the table.
Asians with Uric acid stones had statistically significant lower average age compared to Caucasians. Although there was a trend towards lower BMI, higher uric acid level and lower pH, these didn't reach statistical significance.

Conclusion: Our study shows that Asians suffer from uric acid stone at a younger age and have relatively lower BMI and higher uric acid levels. This correlates with epidemiological studies of Gout from Southeast Asia which confirms a lower age of onset for Gout suggesting that pathogenesis of Gout and Uric acid stones in Asian population is different to Caucasian population. Larger sample size is needed to confirm this finding along with metabolic screening and genetic evaluation for confirming the pathogenesis.
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