Placental Growth factor: another piece in the BPH jigsaw?
BAUS ePoster online library. Devlin C. Jun 26, 2019; 259495; P13-10
Mr. Conor Devlin
Mr. Conor Devlin
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Rate & Comment (0)

Benign prostatic hyperplasia (BPH) is a common disease, whose pathogenesis is not fully understood, although a number of growth factors (GFs) produced by prostate epithelial and stromal layers may play key roles. Current treatments take little account of GF-induced cell proliferation. By studying GF gene expression in enriched prostate cell subtypes we have now identified multiple novel GFs which influence BPH pathogenesis.

Materials and methods

Prostate cell subtypes were enriched directly from fresh BPH biopsies (TURP). GF mRNA array analysis was performed on six BPH samples. Placental growth factor (PGF) protein and receptor expression was validated using western blotting on tissue homogenates, immunocytochemistry on fixed cell subtypes and immunohistochemistry on tissue array samples.


PGF mRNA expression in BPH was more than double that of normal prostate cells. Within BPH tissue, PGF expression was 66 times higher within the stromal population, compared to the epithelial layer. PGF was expressed at the protein level in all homogenate samples. In fixed cells, PGF expression was highest within stromal cells. Interestingly, using formalin fixed tissue arrays, PGF expression was most abundant within the luminal cells, whilst also observed within the stroma. In all preparations, the principal PGF receptor - vascular endothelial growth factor receptor 1 (VEGFR1) was detectable in each cell subtype.


PGF appears to be an important GF in BPH, providing a potential paracrine mechanism for the maintenance of the disease, perhaps mediated by stromal cells. Growth factor receptors could provide a novel source of next-generation, rationally targeted BPH treatments.
    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Save Settings