Oncological outcomes of BCG unresponsive non-muscle invasive bladder cancer patients treated with chemohyperthermia: A multicentre European retrospective analysis.
BAUS ePoster online library. Tan W. 06/24/19; 259512; P2-8
Dr. Wei Shen Tan
Dr. Wei Shen Tan
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We report oncological outcomes of patients with BCG unresponsive disease treated with conductive chemohyperthermia (CHT) in a large multicentre European patient cohort.


CHT was delivered using the Combat BRS system comprised of MMC delivered at 43◦C over 60 minutes. BCG-unresponsive NMIBC was defined as papillary disease ± carcinoma in situ (CIS) <12 months of last BCG instillation, or recurrent high grade papillary disease <6 months of last BCG instillation, or stage T1 disease at first 3 month cystoscopy following induction BCG. Primary endpoint was the 12-month recurrence-free survival (RFS) and the progression-free survival (PFS).

A total of 87 patients from 14 European institutions with a median age of 73.3 years (64.0-79.1) were included. Twenty three patients (26.4%) had CIS only disease, 52 patients (59.8%) with papillary only disease and 12 patients (13.8%) with concurrent CIS and papillary disease. Of the 64 patients with papillary disease, 35 patients (54.7%) had Ta and 29 patients (45.3%) T1 NMIBC. Sixty six patients (75.9%) had high-risk disease. With a median follow-up of 15 (IQR: 8-29) months, 44 patients developed disease recurrence. RFS at 12 months was 55% and at 24 months was 48%. PFS at 24 months was 95%. In patients with CIS disease, 6-month complete response rate was 57%.

BCG-unresponsive NMIBC patients who are treated with CHT delivered using the Combat BRS system had a 24-month DFS of 48% and PFS of 95%. CHT may be an option in NMIBC patients who are unresponsive to BCG.
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