Collagenase clostridium histolyticum injections for Peyronie' s disease – our experience, outcomes and predictive factors for 100 patients
BAUS ePoster online library. Chiriaco G. 06/24/19; 259532; P4-3
Giovanni Chiriaco
Giovanni Chiriaco
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INTRODUCTION: to evaluate the efficacy, safety and predictive factors of collagenase clostridium histolyticum(CCH) in the treatment of Peyronie's disease(PD) using the modified treatment protocol.
a prospective study of 100 men with PD that completed at least 1 course(3 injections) of CCH treatment at a single centre. The majority(80%) received 1 course, with 15%(n=15) and 5%(n=5) completing 2 or 3 courses respectively. The angle of curvature assessment, International Index of Erectile Function (IIEF) and Peyronie's Disease Questionnaire (PDQ) were completed at baseline and 4 weeks after each course. Co-morbidities and risk factors for PD were recorded. The range of curvature improvement was assessed as improvement<14°;15°-20°;and >21°.
The baseline curvature was 54±17°. There was mean improvement of 31%(17±10°) following 1 course . Following a second course there was a 36% improvement from baseline (23.3±10°). After a third course, 52.3%(35 ± 9°) improvement. There were significant improvements in IIEF and PDQ. CCH was well tolerated with one patient experiencing significant side effects (fracture). Overall 12%(n=12) patients experienced transient mild side effects. Following CCH treatment, 10%(10/100) opted for surgical correction. Men with a greater curvature(>70) and PD for greater than 12 months responded significantly better to CCH and were more satisfied.
The modified protocol of CCH is a safe and effective non-surgical treatment option for PD. There is a sustained improvement from baseline penile curvature with second and third courses of treatment. Predictive factors include magnitude of curvature and having PD for more than 1 year.
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