Early Results of Prostatic Urethral Lift in Subjects with Acute Urinary Retention
BAUS ePoster online library. Rochester M. 06/25/19; 259592; P9-6
Mark Rochester
Mark Rochester
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Abstract
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INTRODUCTION

This study is the first assessment of feasibility and safety of Prostatic Urethra Lift (PUL) in patients with acute urinary retention (AUR) secondary to BPO.

METHODS

Males ≥ 50 years of age with symptomatic BPH, prostate volumes ≤ 100 cc, and a failed trial without catheter (TWOC) while on alpha blocker were enrolled. Void trials were performed 3 days post-procedure and IPSS, QoL, BPHII, Qmax and PVR were assessed at 6-week follow-up. Successful first TWOC, mean time to catheter independence, adverse events and surgical interventions were analyzed.

RESULTS

Thirty subjects who underwent PUL across 4 sites in the United Kingdom were enrolled. Mean prostate volume at baseline was 56.9cc and mean duration of most recent retention episode prior to PUL was 83.4 days. Retention status precluded baseline assessments, but at 6-week follow-up mean IPSS (9.7), QoL (1.3), BPHII (1.8), Qmax (8.7ml/s) and PVR (112.1ml) were available for at least 19 patients (Table 1). Results were compared to L.I.F.T 3-month outcomes and revealed many similarities, however, AUR subjects experienced lower QoL and Qmax scores (p < 0.01). Over 60% of AUR subjects achieved a successful TWOC and 70% were catheter free by 1 month. Most adverse events were mild to moderate and resolved within two weeks. Only three subjects experienced serious adverse events that resolved by two weeks and one subject underwent a HoLEP 114 days post-procedure.

Conclusions
PUL facilitates spontaneous micturition in patients suffering from AUR and can offer an alternative to long-term catheter management or more invasive surgery.
INTRODUCTION

This study is the first assessment of feasibility and safety of Prostatic Urethra Lift (PUL) in patients with acute urinary retention (AUR) secondary to BPO.

METHODS

Males ≥ 50 years of age with symptomatic BPH, prostate volumes ≤ 100 cc, and a failed trial without catheter (TWOC) while on alpha blocker were enrolled. Void trials were performed 3 days post-procedure and IPSS, QoL, BPHII, Qmax and PVR were assessed at 6-week follow-up. Successful first TWOC, mean time to catheter independence, adverse events and surgical interventions were analyzed.

RESULTS

Thirty subjects who underwent PUL across 4 sites in the United Kingdom were enrolled. Mean prostate volume at baseline was 56.9cc and mean duration of most recent retention episode prior to PUL was 83.4 days. Retention status precluded baseline assessments, but at 6-week follow-up mean IPSS (9.7), QoL (1.3), BPHII (1.8), Qmax (8.7ml/s) and PVR (112.1ml) were available for at least 19 patients (Table 1). Results were compared to L.I.F.T 3-month outcomes and revealed many similarities, however, AUR subjects experienced lower QoL and Qmax scores (p < 0.01). Over 60% of AUR subjects achieved a successful TWOC and 70% were catheter free by 1 month. Most adverse events were mild to moderate and resolved within two weeks. Only three subjects experienced serious adverse events that resolved by two weeks and one subject underwent a HoLEP 114 days post-procedure.

Conclusions
PUL facilitates spontaneous micturition in patients suffering from AUR and can offer an alternative to long-term catheter management or more invasive surgery.

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